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42 U.S.C. 12111(3)
The term direct threat means a significant risk to the health or safety of others that cannot be eliminated by reasonable accommodation.
42 U.S.C. § 12113 - Defenses
a) In general - It may be a defense to a charge of discrimination under this chapter that an alleged application of qualification standards, tests, or selection criteria that screen out or tend to screen out or otherwise deny a job or benefit to an individual with a disability has been shown to be job-related and consistent with business necessity, and such performance cannot be accomplished by reasonable accommodation, as required under this subchapter.
(b) Qualification standards - The term qualification standards may include a requirement that an individual shall not pose a direct threat to the health or safety of other individuals in the workplace.
29 C.F.R. § 1630.2(r)
...The determination that an individual poses a direct threat shall be based on an individualized assessment of the individual's present ability to safely perform the essential functions of the job. This assessment shall be based on a reasonable medical judgment that relies on the most current medical knowledge and/or on the best available objective evidence.
In determining whether an individual would pose a direct threat, the factors to be considered include:
(1) The duration of the risk;
(2) The nature and severity of the potential harm;
(3) The likelihood that the potential harm will occur; and
(4) The imminence of the potential harm.
29 C.F.R. § 1630.15(b) - Charges of discriminatory application of selection criteria
(1) In general. - It may be a defense to a charge of discrimination, as described in Sec. 1630.10, that an alleged application of qualification standards, tests, or selection criteria that screens out or tends to screen out or otherwise denies a job or benefit to an individual with a disability has been shown to be job-related and consistent with business necessity, and such performance cannot be accomplished with reasonable accommodation, as required in this part.
(2) Direct threat as a qualification standard. - The term qualification standard may include a requirement that an individual shall not pose a direct threat to the health or safety of the individual or others in the workplace.
Chevron
USA, Inc. v. Echazabal, 536 U.S. 73 (2002).
Kapche v. City of San Antonio II, (5th Cir. August 30, 2002).